Fluids are composed of molecules that collide with one another and solid objects. The continuum assumption, however, considers fluids to be continuous. That is, properties such as density, pressure, temperature, and velocity are taken to be well-defined at "infinitely" small points, defining a REV (Reference Element of Volume), at the geometric order of the distance between two adjacent molecules of fluid. Properties are assumed to vary continuously from one point to another, and are averaged values in the REV. The fact that the fluid is made up of discrete molecules is ignored.
The continuum hypothesis is basically an approximation, in the same way planets are approximated by point particles when dealing with celestial mechanics, and therefore results in approximate solutions. Consequently, assumption of the continuum hypothesis can lead to results which are not of desired accuracy. That said, under the right circumstances, the continuum hypothesis produces extremely accurate results.
Those problems for which the continuum hypothesis does not allow solutions of desired accuracy are solved using statistical mechanics. To determine whether or not to use conventional fluid dynamics or statistical mechanics, the Knudsen number is evaluated for the problem. The Knudsen number is defined as the ratio of the molecular mean free path length to a certain representative physical length scale. This length scale could be, for example, the radius of a body in a fluid. (More simply, the Knudsen number is how many times its own diameter a particle will travel on average before hitting another particle). Problems with Knudsen numbers at or above unity are best evaluated using statistical mechanics for reliable solutions.
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